Countless Hours of the Most Up to Date Health Research, and the Acne Puzzle is Finally Solved!

Do you think you have acne because of hormones? Problem solved. Do you think you have acne because of stress? No worries! Not sure why you have acne? It won’t matter, your acne will be cured regardless.

The Focus:Acne Formula is Based From the Newest Medical Research

Don’t get lost in old age medical research. There are new studies undergoing everyday – and because we are able to access these studies, we’ve been capable to create a method that turns even the most severe cases of acne into flawless looking skin!

Lee Song, 24 from Sacramento, CA had tried everything “in the book.” From home remedies, to prescription antibiotics. Nothing worked for him – until he found the Focus:Acne Formula! He finished the program in 3 months time.

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You Can’t Argue With Facts, and if it Works – Why Would You?

We don’t base our program off of what we think will work…

We base it off of what has been proven to work.

Yet most others won’t know about the research we used to compose the Focus:Acne Formula, simply because they have based their ideas on treating acne from old research done as early as the 1950′s!

For instance, most Dermatologists will tell you that your diet plays no role in acne. Yet see what our new age research has discovered…

A substantial body of literature now exists that directly implicates diet as the most likely environmental factor underlying the development of acne.

Cordain, L PhD, Implications for the Role of Diet in Acne

Based on recent scientific reports, a statement has become more and more accepted: there is a lower incidence of acne in non-Western populations. This incidence increases when a Western dietary pattern is adopted.

Adilson CostaI; Denise Lage; Thaís Abdalla Moisés, Acne and diet: truth or myth?

You can scroll through the text-box below to see more than a hundred more clinical studies that were used as research to compose the Focus:Acne Formula.

1. Thiboutot DM, Strauss JS: Diseases of the sebaceous glands, in Freedberg IM, Eisen AZ, Wolff K, et al, (eds.): Fitzpatrick's Dermatology in General Medicine, vol 1. (ed 6). New York: McGraw-Hill, 2003 p 683
2. Cunliffe WJ, Simpson NB: Disorders of sebaceous glands. In: Champion RH, Wilkinson DS, Ebling FJG, et al, (eds): Rook/Wilkinson/Ebling Textbook of Dermatology (ed 6). Oxford: Blackwell Science, Ltd, 1998 p 1951
3. Green J, Sinclair RD: Perceptons of acne vulgaris in final year medical student written examination answers. Austr J Dermatol 42:98-101, 2001
4. Loeffel ED: Foods and acne. J Tenn Med Assoc 65:918, 1972
5. Kaminester LH: Acne. JAMA 239:2171-2172, 1978
6. Michaelsson G: Diet and acne. Nutr Rev 39:104-106, 1981
7. Rasmussen JE: Diet and acne. Int J Dermatol 16:488-492, 1977
8. Bershad S: The unwelcome return of the acne diet. Arch Dermatol 139:940-941, 2003
9. Smolinski KN, Yan AC: Acne update: 2004. Curr Opin Pediatr 16: 385-391, 2004
10. Lehmann HP, Robinson KA, Andrews JS, et al: Acne therapy: a methodologic review. J Am Acad Dermatol 47:231-240, 2002
11. Anderson PC: Foods as the cause of acne. Am J Fam Pract 3:102-103, 1971
12. Fulton JE, Plewig G, Kligman AM: Effect of chocolate on acne vulgaris. JAMA 210:2071-2074, 1969
13. Treloar V: Diet and acne redux. Arch Dermatol 139:941, 2003
14. Cordain L: In reply. Arch Dermatol 139:942-943, 2003
15. Burkhart CN, Gottwald L: Assessment of etiologic agents in acne pathogenesis. Skin Med 2:222-228, 2003
16. Mullins JF, Naylor D: Glucose and the acne diathesis: an hypothesis and review of pertinent literature. Tex Rep Biol Med 20:161-175, 1962
17. Foster-Powell K, Holt SH, Brand-Miller JC: International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76:5-56, 2002
18. Gollnick H: Current concepts of the pathogenesis of acne. Drugs 63:1579-1596, 2003
19. Cunliffe WJ, Holland DB, Clark SM, et al: Comedogenesis: some aetiological,clinical and therapeutic strategies. Dermatology 206:11-6, 2003 Harper JC, Thiboutot DM: Pathogenesis of acne: recent research advances Adv Dermatol 19:1-10, 2003
21. Pawin H, Beylot C, Chivot M, et al: Physiopathology of acne vulgaris: recent data, new understanding of the treatments. Eur J Dermatol 14:4-12, 2004
22. Pochi PE, Shalita AR, Strauss JS, et al: Report of the Consensus Conference on Acne Classification. Washington, DC, March 24 and 25, 1990. J Am Acad Dermatol 24:495-500, 1991
23. White GM: Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol 39:S34-7, 1998
24. Goulden V, Stables GI, Cunliffe WJ: Prevalence of facial acne in adults. J Am Acad Dermatol 41:577-580, 1999
25. Rademaker M, Garioch JJ, Simpson NB: Acne in schoolchildren: no longer a concern for dermatoloigsts. Br Med J 298:1217-1219, 1989
26. Kilkenny M, Merlin K, Plunkett A, et al: The prevalence of common skin conditions in Australian school students: 3. acne vulgaris. Br J Dermatol 139:840-845, 1998
27. Lello J, Pearl A, Arroll B, et al: Prevalence of acne vulgaris in Auckland senior high school students. N Z Med J 108:287-289, 1995
28. Hansman FS: Biochemistry in relation to the aetiology of acne vulgaris. Aust J Dermatol 1:120-124, 1951
29. Schaefer O: When the Eskimo comes to town. Nutr Today 6:8-16, 1971
30. Steiner PE: Necropsies on Okinawans. Anatomic and pathologic observations. Arch Pathol 42:359-380, 1946
31. Cordain L, Lindeberg S, Hurtado M, et al: Acne vulgaris: a disease of Western civilization. Arch Dermatol 138:1584-1590, 2002
32. Goulden V, McGeown CH, Cunliffe WJ: The familial risk of adult acne: a comparison between first-degree relatives of affected and unaffected individuals. Br J Dermatol 141:297-300, 1999
33. Toyoda M, Morohashi M: Pathogenesis of acne. Med Electron Microsc 34:29-40, 2001
34. Oh CW, Myung KB: An ultrastructural study of the retention hyperkeratosis of experimentally induced comedones in rabbits: the effects of three comedolytics. J Dermatol 23:169-180, 1996
35. Maeda T: An electron microscopic study of experimentally-induced comedo and effects of vitamin A acid on comedo formation. J Dermatol 18:397-407, 1991
36. Zelickson AS, Strauss JS, Mottaz J: Ultrastructural changes in open comedones following treatment of cystic acne with isotretinoin. Am J Dermatopathol 7:241-244, 1985
37. Woo-Sam PC: The effect of vitamin A acid on experimentally induced comedones: an electron microscope study. Br J Dermatol 100:267-276, 1979
38. Woo-Sam PC: Cohesion of horny cells during comedo formation. An electron microscope study. Br J Dermatol 97:609-615, 1977
39. Knaggs HE, Holland DB, Morris C, et al: Quantification of cellular proliferation in acne using the monoclonal antibody Ki-67. J Invest Dermatol 102:89-92, 1994
40. Jenkins DJ, Wolever TM, Taylor RH, et al: Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 34: 362-366, 1981
41. Liu S, Willett WC: Dietary glycemic load and atherothrombotic risk. Curr Atheroscler Rep 4:454-461, 2002
42. Holt SH, Miller JC, Petocz P: An insulin index of foods: the insulin demand generated by 1000-kJ portions of common foods. Am J Clin Nutr 66:1264-1276, 1997
43. Ostman EM, Liljeberg Elmstahl HG, Bjorck IM: Inconsistency between glycemic and insulinemic responses to regular and fermented milk products. Am J Clin Nutr 74:96-100, 2001
44. Gerrior S, Bente L: Nutrient Content of the U.S. Food Supply, 1909-99: A Summary Report. U.S. Department of Agriculture, Center for Nutrition Policy and Promotion. Home Economics Report No. 55, 2002
45. Kiens B, Richter EA: Types of carbohydrate in an ordinary diet affect insulin action and muscle substrates in humans. Am J Clin Nutr 63:47-53, 1996
46. Ludwig DS: The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA 8;287:2414- 2423, 2002
47. Liu S, Willett WC: Dietary glycemic load and atherothrombotic risk. Curr Atheroscler Rep 4:454-461, 2002
48. Edmondson SR, Thumiger SP, Werther GA, et al: Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems. Endocr Rev 24:737-764, 2003
49. Nam SY, Lee EJ, Kim KR, et al: Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone Int J Obes Relat Metab Disord 21:355-359, 1997
50. Attia N, Tamborlane WV, Heptulla R, et al: The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity. J Clin Endocrinol Metab 83:1467-1471, 1998
51. Brismar K, Fernqvist-Forbes E, Wahren J, et al: Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-1 in insulin dependent diabetes. J Clin Endocrinol Metab 79:872-878, 1994
52. Holly JMP: The physiological role of IGFBP-1. Acta Endocrinol 124: 55-62, 1991
53. Wong WW, Copeland KC, Hergenroeder AC, et al: Serum concentrations of insulin, insulin-like growth factor-I and insulin-like growth factor binding proteins are different between white and African American girls. J Pediatr 135:296-300, 1999
54. Loche S, Cappa M, Borrelli P, et al: Reduced growth hormone response to growth hormone-releasing hormone in children with simple obesity: evidence for somatomedin-C mediated inhibition. Clin Endocrinol (Oxf) 27:145-153, 1987
55. Liu VR: The Glycemic index and the insulin-like growth factor system. Honours Thesis. Human Nutrition Unit, Department of Biochemistry, University of Sydney, Sydney, Australia, , 2000
56. Boden G, Shulman GI: Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and betacell dysfunction. Eur J Clin Invest 32(Suppl 3):14-23, 2002
57. Vacaresse N, Lajoie-Mazenc I, Auge N, et al: Activation of epithelial growth factor receptor pathway by unsaturated fatty acids. Circ Res 85:892-899, 1999
58. Wolever TM, Mehling C: Long-term effect of varying the source or amount of dietary carbohydrate on postprandial plasma glucose, insulin, triacylglycerol, and free fatty acid concentrations in subjects with impaired glucose tolerance. Am J Clin Nutr 77:612-621, 2003
59. Lee KW, Cohen P. Nuclear effects: unexpected intracellular actions of insulin-like growth factor binding protein-3. J Endocrinol 175:33-40, 2002
60. Barbieri RL, Smith S, Ryan KJ: The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism Fertil Steril 50:197-212, 1998
61. Cara JF: Insulin-like growth factors, insulin-like growth factor binding proteins and ovarian androgen production. Horm Res 42:49-54, 1994
62. Bebakar WM, Honour JW, Foster D, et al: Regulation of testicular function by insulin and transforming growth factor-beta. Steroids 55:266-270, 1990
63. De Mellow JS, Handelsman DJ, Baxter RC: Short-term exposure to insulin-like growth factors stimulates testosterone production by testicular interstitial cells. Acta Endocrinol 115:483-489, 1987
64. Crave JC, Lejeune H, Brebant C, et al: Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cells. J Clin Endocrinol Metab 80:1283-1289, 1995
65. Singh A, Hamilton-Fairley D, Koistinen R, et al: Effect of insulin-like growth factor-type I (IGF-I) and insulin on the secretion of sex hormone binding globulin and IGF-I binding protein (IBP-I) by human hepatoma cells. J Endocrinol 124:R1-R3, 1990
66. Pugeat M, Crave JC, Elmidani M, et al: Pathophysiology of sex hormone binding globulin (SHBG): relation to insulin. J Steroid Biochem Mol Biol 40:841-849, 1991
67. Vermeulen A, Kaufman JM, Giagulli VA: Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 81:1821-1826, 1996
68. Pfeilschifter J, Scheidt-Nave C, Leidig-Bruckner G, et al: Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women. J Clin Endocrinol Metab 81:2534-2540, 1996
69. Erfurth EM, Hagmar LE, Saaf M, et al: Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men. Clin Endocrinol 44:659-664, 1996
70. Zouboulis CC, Xia L, Akamatsu H, et al: The human sebocyte culture model provides new insights into development and management of seborrhoea and acne. Dermatology 196:21-31, 1998
71. Deplewski D, Rosenfield RL: Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinology 140:4089-4094, 1999
72. Klinger B, Anin S, Silbergeld A, et al: Development of hyperandrogenism during treatment with insulin-like growth hormone factor-I (IGF-1) in female patients with Laron syndrome Clin Endocrinol 48:81-87, 1998
73. Thiboutot D, Gilliland K, Light J, et al: Androgen metabolism in sebaceous glands from subjects with and without acne. Arch Dermatol 135:1041-1045, 1999
74. Aizawa H, Niimura M: Elevated serum insulin-like growth factor-I (IGF-1) levels in women with postadolescent acne. J Dermatol 22: 249-252, 1995
75. Aizawa H, Niimura M: Mild insulin resistance during oral glucose tolerance test (OGTT) in women with acne. J Dermatol 23:526-529, 1996
76. Vowels BR, Yang S, Leyden JJ: Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infect Immun 63:3158-3165, 1995
77. Webster GF, Leyden JJ, Tsai CC, et al: Polymorphonuclear leukocyte lysosomal release in response to Propionibacterium acnes in vitro and its enhancement by sera from inflammatory acne patients. J Invest Dermatol 74:398-401, 1980
78. Norris JF, Cunliffe WJ: A histological and immunocytochemical study of early acne lesions. Br J Dermatol 118:651-659, 1988
79. Guy R, Kealey T: Modelling the infundibulum in acne Dermatology. 196:32-37, 1998
80. Simopoulos AP: Omega-3 fatty acids in inflammation and autoimmune diseases J Am Coll Nutr 21:495-505, 2002
81. Kris-Etherton PM, Taylor DS, Yu-Poth S, et al: Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr 71:179S-188S, 2000 (Suppl 1)
82. Cordain L, Watkins BA, Florant GL, et al: Fatty acid analysis of wild ruminant tissues: evolutionary implications for reducing diet-related chronic disease. Eur J Clin Nutr 56:181-191, 2002
83. Endres S, Ghorbani R, Kelley VE, et al: The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 320:265-271, 1989
84. Meydani SN, Endres S, Woods MM, et al: Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J Nutr 121:547-555, 1991
85. James MJ, Gibson RA, Cleland LG: Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71:343S-348S, 2000 (Suppl 1)
86. Mayer K, Meyer S, Reinholz-Muhly M, et al: Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans. J Immunol 171:4837-4843, 2003
87. Zhao Y, Joshi-Barve S, Barve S, et al: Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation. J Am Coll Nutr 23:71-78, 2004
88. Trebble T, Arden NK, Stroud MA, et al: Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation. Br J Nutr 90:405-412, 2003
89. Zouboulis CC, Nestoris S, Adler YD et al: Treatment of inflammatory acne with an oral 5-lipoxygenase inhibitor. J Invest Dermatol 117: 547, 2001
90. Cohen JL, Cohen AD: Pustular acne, staphyloderma and its treatment with tolbutamide. Can Med Assoc J 80:629-632, 1959
91. Bettley FR: The treatment of acne vulgaris with tolbutamide. Br J Dermatol 73:149-151, 1961
92. Singh I, Gaind ML, Jayram D: Tolbutamide in the treatment of skin diseases. Br J Dermatol 73:362-366, 1961
93. Depaoli M, Martina G: The therapeutic action of tolbutamide in common acne and acne rosacea. Panimnerva Med 365-366, 1961
94. Flinn JH: The treatment of acne with tolbutamide. Stud Med 9:234-237, 1961
95. Rustenbeck I: Desensitization of insulin secretion. Biochem Pharmacol 63:1921-1935, 2002
96. Falsetti L, Eleftheriou Gl: Hyperinsulinemia in the polycystic ovary syndrome: a clinical endocrine and echographic study in 240 patients. Gynecol Endocrinol 10:319-326, 1996
97. Nestler JE: Insulin regulation of human ovarian androgens. Hum Reprod 12(Suppl 1):53-62, 1997
98. Thierry van Dessel HJ, Lee PD, Faessen G, et al: Elevated serum levels of free insulin like growth factor-I levels in polycystic ovary syndrome. J Clin Endocrinol Metab 84:3030-3035, 1999
99. Pasquali R, Casimirri F, Vicennati V: Weight control and its beneficial effect on fertility in women with obesity and polycystic ovary syndrome. Hum Reprod 12(Suppl 1):82-87, 1997
100. Ehrmann DA: Insulin-lowering therapeutic modalities for polycystic ovary syndrome. Endocrinol Metab Clin North Am 28:423-438, 1999
101. Kolodziejczyk B, Duleba AJ, Spaczynski RZ, et al: Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil Steril 73:1149-1154, 2000
102. Romualdi D, Guido M, Ciampelli M, et al: Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome. Hum Reprod 18:1210-1218, 2003
103. Arslanian SA, Lewy V, Danadian K, et al: Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance. J Clin Endocrinol Metab 87:1555-1559, 2002
104. Guido M, Romualdi D, Suriano R, et al: Effect of pioglitazone treatment on the adrenal androgen response to corticotrophin in obese patients with polycystic ovary syndrome Hum Reprod 19:534-539, 1994
105. Bourne S, Jacobs A: Observations on acne, seborrhea, and obesity. BMJ 1:1268-1270, 1956
106. Berrino F, Bellati C, Secreto G, et al: Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgen (DIANA) randomized trial. Cancer Epidemiol Biomarkers Prev 10:25-33, 2001

To better show just some of what our research has found, watch the video below.


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